An amino acid sequence from the middle region of human ABCG4 (AVQNGLCAMAEKKSS) was used as the immunogen for this ABCG4 antibody.
ATP-Binding Cassette, Subfamily G, Member 4 is a protein that in humans is encoded by the ABCG4 gene. The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. This protein is a member of the White subfamily and is expressed predominantly in liver tissue. By genomic sequence analysis, Engel et al.(2001) mapped the gene to chromosome 11q23.3. Engel et al.(2001) demonstrated 5-fold induction of ABCG4 following treatment of normal monocyte-derived macrophages with the LXR and RXR agonists 9-cis retinoic acid and 22R hydroxycholesterol. Removal of cholesterol from macrophages by cyclodextrin decreased ABCG4 message levels.
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Purity:
Antigen affinity
Form:
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Antibody Type:
Primary Antibody
Application Dilute:
Western blot: 0.5-1ug/ml
Application Notes:
The stated application concentrations are suggested starting amounts. Titration of the ABCG4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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