An amino acid sequence from the middle region of human TNF Receptor-Associated Factor 3 (RHDQMLSVHDIRLADMD) was used as the immunogen for this TRAF3 antibody (100% homologous in human, mouse and rat).
TNF Receptor-Associated Factor 3, also called LAP1, CAP1, CRAF1 or CD40BP, is a protein that in humans is encoded by the TRAF3 gene. The protein encoded by this gene is a member of the TNF receptor(TNFR) associated factor (TRAF) protein family. Gross(2012) mapped the gene to chromosome 14q32.32 based on an alignment of the TRAF3 sequence with the genomic sequence (GRCh37). Dadgostar et al.(2003) determined that the coiled-coil domain of mouse T3JAM interacted with the isoleucine zipper domain of Traf3. Oganesyan et al.(2006) demonstrated that cells lacking TRAF3 are defective in type I interferon responses activated by several different Toll-like receptors.
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Purity:
Antigen affinity
Form:
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Antibody Type:
Primary Antibody
Application Dilute:
Western blot: 0.5-1ug/ml
Application Notes:
The stated application concentrations are suggested starting amounts. Titration of the TRAF3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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