ZO-2 Antibody / Zona Occludens 2, Rabbit, Polyclonal
Biozol Catalog Number:
NSJ-R31060
Supplier Catalog Number:
R31060
Alternative Catalog Number:
NSJ-R31060
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
FACS, IF, IHC-P, WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
A synthetic peptide corresponding to human Zona occludens 2 (SEHSKRGYYGQSARYRDTEL) was used as the immunogen for this ZO-2 antibody.
Tight Junction Protein 2, also known as Zona occludens 2 or ZO-2 is a protein that in humans is encoded by the TJP2 gene. Tight junction proteins (TJPs), or zonulae occludentes, belong to a family of membrane-associated guanylate kinase (MAGUK) homologs that are involved in the organization of epithelial and endothelial intercellular junctions. Duclos et al.(1994) mapped the gene telomeric to the Friedreich ataxia critical region on chromosome 9q13-q21. It lies about 70 kb centromeric to the X123 gene and is transcribed in the centromere-to-telomere direction. Using in vitro assays and immunoprecipitation studies, Itoh et al.(1999) showed that the mouse Tjp1, Tjp2, and Tjp3 PDZ1 domains interacted with the C-terminal cytoplasmic domains of Cldn1 through Cldn8. In the mouse inner ear, Walsh et al.(2010) found that Tjp2 expression decreased rapidly between E16.5 and age 1 week to a level in adult mice that was approximately 50% of the level at birth(P0).
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Purity:
Antigen affinity
Form:
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Antibody Type:
Primary Antibody
Application Dilute:
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 2-5ug/ml,Immunofluorescence: 5ug/ml,Flow cytometry: 1-3ug/million cells
Application Notes:
The stated application concentrations are suggested starting amounts. Titration of the ZO-2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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