NRF1 Antibody / Nuclear Respiratory Factor 1, Rabbit, Polyclonal

Catalog Number: NSJ-R31050

Article Name:	NRF1 Antibody / Nuclear Respiratory Factor 1, Rabbit, Polyclonal
Biozol Catalog Number:	NSJ-R31050
Supplier Catalog Number:	R31050
Alternative Catalog Number:	NSJ-R31050
Manufacturer:	NSJ Bioreagents
Host:	Rabbit
Category:	Antikörper
Application:	ICC, IHC-P, WB
Species Reactivity:	Human, Mouse, Rat
Immunogen:	An amino acid sequence from the middle region of human Nuclear Respiratory Factor 1 (QHGREDLLYAFEDQQTQ) was used as the immunogen for this NRF1 antibody (100% homologous in human, mouse and rat).

Nuclear Respiratory Factor 1 is also known as Alpha-Pal. Efiok et al.(1994) identified genes containing NRF1-binding sequences and found that these could be classified either as cellular proliferation genes, or as genes regulating the growth-responsive metabolic pathways of energy transduction, translation, and replication. Virbasius and Scarpulla (1994) noted that the nuclear-encoded mitochondrial transcription factorTFAMcontains potential binding sites for NRF1, NRF2(GABPA) and SP1 within the promoter region. With use of binding and electrophoretic mobility shift assays, DNase footprinting, and mutation analysis of recombinant proteins, they demonstrated specific and functional binding of NRF1and NRF2to the TFAM promoter region.

Clonality:	Polyclonal
UniProt:	Q16656
Buffer:	Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Purity:	Antigen affinity
Form:	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Antibody Type:	Primary Antibody

Application Dilute:	Western blot: 0.5-1ug/ml,IHC (FFPE): 0.5-1ug/ml,Immunocytochemistry: 0.5-1ug/ml
Application Notes:	The stated application concentrations are suggested starting amounts. Titration of the NRF1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

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