Recombinant human protein was used as the immunogen for the CCR4-NOT transcription complex subunit 4 antibody.
CNOT4 has intrinsic E3 ubiquitin ligase activity. Binding of the CNOT4 RING finger to the ubiquitin-conjugating enzyme (E2) UbcH5B is highly selective. The CCR4-NOT complex functions as a global regulator of RNA polymerase II transcription.
The stated application concentrations are suggested starting points. Titration of the CCR4-NOT transcription complex subunit 4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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