A portion of amino acids 131-160 from the mouse protein was used as the immunogen for the Map3k7 antibody.
Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.
Immunohistochemistry (FFPE): 1:25, Western blot: 1:500-1:2000
Application Notes:
The stated application concentrations are suggested starting points. Titration of the Map3k7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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