A portion of amino acids 200-227 from the human protein was used as the immunogen for the CLDN2 antibody.
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5 untranslated region have been found for this gene.
The stated application concentrations are suggested starting points. Titration of the CLDN2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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