Angiotensin II Type 1 Receptor Antibody / AGTR1 / AT1R, Rabbit, Polyclonal
Biozol Catalog Number:
NSJ-F54336-0.08ML
Supplier Catalog Number:
F54336-0.08ML
Alternative Catalog Number:
NSJ-F54336-0.08ML
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
FACS, IF, IHC-P, WB
Species Reactivity:
Human, Mouse
Immunogen:
A portion of amino acids 211-240 from the human protein was used as the immunogen for the Angiotensin II Type 1 Receptor antibody.
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed, however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq].
The stated application concentrations are suggested starting points. Titration of the Angiotensin II Type 1 Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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