A portion of amino acids 80-109 from the human protein was used as the immunogen for the RHBDF2 antibody.
Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. [UniProt]
Western blot: 1:500-1:2000,Immunohistochemistry (FFPE): 1:25
Application Notes:
The stated application concentrations are suggested starting points. Titration of the RHBDF2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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