A portion of amino acids 575-603 from the mouse protein was used as the immunogen for the Lingo1 Antibody.
Leucine-rich repeat and immunoglobulin domain-containing protein 1 is the functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. LINGO1 is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. [UniProt]
Western blot: 1:500-1:2000,Immunohistochemistry (FFPE): 1:25
Application Notes:
The stated application concentrations are suggested starting points. Titration of the Lingo1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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