A portion of amino acids 159-193 from the human protein was used as the immunogen for the HIPPI antibody.
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5-AAAGACATG-3 present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator, however the relevance of such function remains unclear.
The stated application concentrations are suggested starting points. Titration of the HIPPI antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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