Recominant human Thioredoxin protein was used as the immunogen for the Thioredoxin antibody.
Thioredoxin / TRX / TXN participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
The stated application concentrations are suggested starting points. Titration of the Thioredoxin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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