Recombinant human RAB7L1 was used as the immunogen for the RAB7L1 antibody.
Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans- Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection. [UniProt]
The stated application concentrations are suggested starting points. Titration of the RAB7L1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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