A human recombinant partial protein was used as the immunogen for this TLR3 antibody.
Toll like Receptor 3 is a key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. [UniProt]
The stated application concentrations are suggested starting points. Titration of the TLR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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