A human recombinant protein was used as the immunogen for this HtrA2 antibody.
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. [UniProt]
The stated application concentrations are suggested starting points. Titration of the HtrA2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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