Amino acids 518-551 from the human protein were used as the immunogen for this INTS3 antibody.
Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.
The stated application concentrations are suggested starting points. Titration of the INTS3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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