This HSP-90 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 644-677 amino acids from the C-terminal region of human HSP90AA1.
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
The stated application concentrations are suggested starting points. Titration of the HSP-90 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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