A portion of amino acids 118-147 from the human protein was used as the immunogen for this PINK1 antibody.
Defects in PINK1 are the cause of autosomal recessive early-onset Parkinsons disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinsons disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.
The stated application concentrations are suggested starting amounts. Titration of the PINK1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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