AXIN2 Antibody / Axis inhibition protein 2, Rabbit, Polyclonal
Biozol Catalog Number:
NSJ-F49172-0.4ML
Supplier Catalog Number:
F49172-0.4ML
Alternative Catalog Number:
NSJ-F49172-0.4ML
Manufacturer:
NSJ Bioreagents
Host:
Rabbit
Category:
Antikörper
Application:
ELISA, FACS, IHC, WB
Species Reactivity:
Human
Immunogen:
A portion of amino acids 816-843 from the human protein was used as the immunogen for this AXIN2 antibody.
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
