A portion of amino acids 1141-1166 from the human protein was used as the immunogen for this ERBB4 antibody.
ERBB4 acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. [UniProt]
