S217879 is an orally active and selective NRF2 activator. S217879 activates the NRF2 pathway by specifically disrupting the KEAP1 (Kd: 4.15 nM)-NRF2 interaction, and upregulates the antioxidant response. S217879 also ameliorates steatohepatitis and reduces the degree of liver fibrosis. S217879 can be used in the research of metabolic dysfunction-associated steatotic liver disease and nonalcoholic steatohepatitis[1][2].
Molecular Weight:
592.66
CAS Number:
[2700303-28-0]
Formula:
C30H32N4O7S
Target:
Interleukin Related,Keap1-Nrf2,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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