Norbinaltorphimine dihydrochloride (nor-Binaltorphimine dihydrochloride, nor-BNI dihydrochloride) is a selective, long-acting competitive antagonist of the kappa-opioid receptor. Norbinaltorphimine dihydrochloride blocks kappa-opioid receptor-mediated analgesic effects, and inhibits butorphanol-induced changes in kappa-opioid receptor binding kinetics, desensitization and down-regulation. Norbinaltorphimine dihydrochloride suppresses specific opioid withdrawal symptoms, precipitates withdrawal behaviors in butorphanol-dependent rats, and serves as a molecular probe for studying kappa-opioid receptor-agonist interactions. Norbinaltorphimine dihydrochloride is applicable to research related to neurological disorders such as pain[1][2][3].
Molecular Weight:
734.71
Purity:
98.91
CAS Number:
[113158-34-2]
Formula:
C40H45Cl2N3O6
Target:
Opioid Receptor
Application Notes:
MCE Product type: Reference compound
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