Cimicoxib (Standard), CAS [[265114-23-6]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-100516R
Supplier Catalog Number:
HY-100516R
Alternative Catalog Number:
MCE-HY-100516R-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
Alternative Names:
UR-8880 (Standard)
Cimicoxib (Standard) is the analytical standard of Cimicoxib. This product is intended for research and analytical applications. Cimicoxib (UR-8880) is an orally active, blood-brain barrier-permeable COX-2 inhibitor that also exerts targeted inhibition on CYP2D15. It has an IC50 of 66 nM against hCOX-2, an IC50 of 1.6 µM against canine CYP2D15, and an IC50 of 0.056 µM against feline CYP2D15. By inhibiting the COX-2 pathway to reduce the production of thromboxane B2 and prostaglandin E2, Cimicoxib exerts antipyretic, anti-inflammatory and analgesic effects. Cimicoxib is metabolized by CYP2D15 to form demethyl-cimicoxib, undergoes glucuronidation via UDP-glucuronosyltransferases, and exhibits biphasic elimination kinetics in beagle dogs. Cimicoxib is widely used in studies of inflammatory diseases, osteoarthritis, and perioperative pain associated with orthopedic or soft tissue surgeries[1][2][3][4][5].
Molecular Weight:
381.81
CAS Number:
[265114-23-6]
Formula:
C16H13ClFN3O3S
Target:
COX,Cytochrome P450,Reference Standards
Application Notes:
MCE Product type: Reference Standards
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