Chemical Name: N-[2-(4-Morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-tyrosinamide. Alternate Names: PR-957
Immunoproteasome inhibitor
Molecular Weight:
580.68
Purity:
>98% by HPLC NMR (Conforms)
Form:
White solid
CAS Number:
[960374-59-8]
Formula:
C31H40N4O7
Application Notes:
ONX-0914 (960374-59-8) is a selective inhibitor of the LMP7 subunit of the immunoproteasome (IC50 = 65 nM for mouse) which is the chymotrypsin-like subunit.1 Treatment with ONX-0914 resulted in suppression of Th1 and Th17 cells but enhancement of regulatory T cell differentiation in mouse models of induced colitis.2 ONX-0914 retards rheumatoid arthritis progression3, ameliorates diabetic cardiomyopathy4 and attenuates atherosclerosis and metabolic syndrome in mice5.
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