Chemical Name: 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
GSK-3ß inhibitor
Molecular Weight:
318.34
Purity:
>98% by HPLC NMR (Conforms)
Form:
Off-white to beige solid
CAS Number:
[601514-19-6]
Formula:
C18H14N4O2
Application Notes:
TWS-119 is a potent inhibitor of GSK-3ß (IC50 = 30 nM).1 At higher concentrations (400 nM), it induces neurogenesis in mouse embryonic stem cells.1 It maintained hepatic stellate cells in the quiescent state.2 TWS119 treatment increased the amount of stem cell-like memory CD8+ T cells3, enhanced metabolic fitness of CD8+ T cells4, and prevented CD8+ differentiation5. It displayed neuroprotective effects in models of cerebral ischemia.6,7 TWS119 greatly increased the efficacy of NK cells against myeloma.8
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