Chemical Name: N-(2-Amino-4-fluorophenyl)-4-[[[(E)-3-pyridin-3-ylprop-2-enoyl]amino]methyl]benzamide. Alternate Names: Chidamide
Class I HDAC inhibitor
Molecular Weight:
390.42
Purity:
>98% by HPLC NMR (Conforms)
Form:
White solid
CAS Number:
[1616493-44-7]
Formula:
C22H19FN4O2
Application Notes:
Tucidinostat is a potent inhibitor of Class I HDACs (IC50s: HDAC1 = 95 nM, HDAC2 = 160 nM, HDAC3 = 67 nM, HDAC 8 = 733 nM, also inhibits HDAC10, 78 nM).1 It increased the efficacy and persistence of CAR-T cells.2 Tucidinostat displayed efficacy against multiple types of cancer.3,4
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