Chemical Name: Methyl 3-[[2-[4-(1-adamantyl)phenoxy]acetyl]amino]-4-hydroxybenzoate
Malate dehydrogenase inhibitor
Molecular Weight:
435.52
Purity:
>98% by HPLC NMR (Conforms)
Form:
Off-white to light gray solid
CAS Number:
[934593-90-5]
Formula:
C26H29NO5
Application Notes:
LW6 is an inhibitor of malate dehydrogenase (MDH) (IC50s: MDH1 = 1.1 µM, MDH2 = 6.3 µM).1,2 It inhibits Hypoxia-Inducible Factor-1 (HIF-1) by a variety of reported mechanisms.3-5 LW6 displayed antitumor properties in hepatocellular6 and pancreatic cancer7 cell lines. It promoted rat locomotor function after spinal cord injury via reduction of neuroinflammation.8
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