SENP1 (18B5) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE17723
Product Overview
Article Name:
SENP1 (18B5) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE17723
Supplier Catalog Number:
AMRe17723
Alternative Catalog Number:
EKL-AMRE17723-50UL, EKL-AMRE17723-100UL, EKL-AMRE17723-200UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
FC, ICC, IHC, WB
Species Reactivity:
Human
Conjugation:
Unconjugated
Alternative Names:
SENP1, SuPr2,
Product Description
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed: 15199155, PubMed: 16253240, PubMed: 16553580, PubMed: 21829689, PubMed: 21965678, PubMed: 23160374, PubMed: 24943844, PubMed: 25406032, PubMed: 29506078). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (PubMed: 16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed: 21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed: 23160374). Deconjugates SUMO2 from MTA1 (PubMed: 21965678). Deconjugates SUMO1 from METTL3 (PubMed: 29506078). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed: 25406032). Deconjugates SUMO1 from GPS2 (PubMed: 24943844).
Product Properties
Clonality:
Monoclonal
Molecular Weight:
73kDa
NCBI:
29843
UniProt:
Q9P0U3
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity:
Affinity purification
Form:
Liquid
Target:
SENP1
Application Notes
Application Dilute:
WB 1:1000-1:10000,IHC 1:100-1:200,ICC/IF 1:100-1:500,FC 1:20-1:50
