S100 (1E16) Rabbit Monoclonal Antibody, Unconjugated

Catalog Number: EKL-AMRE17458
Article Name: S100 (1E16) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number: EKL-AMRE17458
Supplier Catalog Number: AMRe17458
Alternative Catalog Number: EKL-AMRE17458-50UL, EKL-AMRE17458-100UL, EKL-AMRE17458-200UL
Manufacturer: EnkiLife
Host: Rabbit
Category: Antikörper
Application: IF, IHC, WB
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Alternative Names: Bpb, NEF, Protein S100-A1, S100 beta, S100 calcium binding protein A1, S100A, S100B, 100beta,
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes (PubMed:23351007). These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290). Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446).
Clonality: Monoclonal
Molecular Weight: 11kDa
NCBI: 6271
UniProt: P23297
Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity: Affinity purification
Form: Liquid
Target: S100A1
Application Dilute: WB 1:500-1:2000,IHC 1:100-1:200,IF-P 1:100-1:200



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