Ras-associated, small GTP-binding protein, rat, recombinant, E. coli
Rab5A is a small GTPase that belongs to the Ras superfamily. Rab proteins play an important role in various aspects of membrane traffic, including cargo selection, vesicle budding, vesicle motility, tethering, docking, and fusion. The small Rab5A GTPase is localized to plasma membrane, clathrin coated vesicles, caveosomes and early endosomes. Rab5 is a key regulator of the early endocytic pathway and plays a role in early endosome fusion and caveolar vesicle targeting to early endosomes. Furtermore it is also implicated in EGF receptor activation and apoptotic cell engulfment.
Molecular Weight:
Theoretical MW: 24 kDa
Source:
rat
Purity:
> 90% (SDS-PAGE)
Form:
liquid (Supplied in 25 mM HEPES pH 7.2, 40 mM NaCl, 2 mM MgCl 2, 10 µM GDP and 3 mM TCEP)
Application Notes:
Biological Origin: rat. Biological Activity: 100 pmol of protein can bind > 80 pmol of GDP
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