I-287 is a selective, orally bioavailable PAR2 negative allosteric modulator that inhibits Galphaq and Galpha12/13 signaling. It has demonstrated efficacy in reducing inflammatory pain in murine CFA models, supporting its use as a research tool for studying inflammation, immune responses, and protease-activated receptor pathways in both in vitro and in vivo settings.
Molecular Weight:
565.04
CAS Number:
[2014368-93-3]
Formula:
C30H30ClFN4O4
Target:
ERK,Protease-activated Receptor,Others
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