Compound 31q is a dual-action small molecule functioning as an ERalpha degrader (K I = 75 nM) and an aromatase (ARO) inhibitor (IC50 = 37.7 nM). It demonstrates potent antitumor efficacy in MCF-7 xenograft models, supporting its use in breast cancer research for investigating endocrine resistance mechanisms.
Molecular Weight:
568.57
Formula:
C28H23F3N4O4S
Target:
Cytochromes P450,Estrogen Receptor/ERR
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