A011 is a potent and selective ATM kinase inhibitor with an IC50 of 1.0 nM. In research, it induces apoptosis and G2/M arrest when combined with CPT-11 (irinotecan), demonstrating antitumor efficacy in both cellular and in vivo models.
Molecular Weight:
452.55
Formula:
C27H28N6O
Target:
Apoptosis,ATM/ATR
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