VTP50469, CAS [[2169916-18-9]]
Catalog Number:
BYT-ORB1308940
Product Overview
Article Name:
VTP50469, CAS [[2169916-18-9]]
Biozol Catalog Number:
BYT-ORB1308940
Supplier Catalog Number:
orb1308940
Alternative Catalog Number:
BYT-ORB1308940-1,BYT-ORB1308940-10,BYT-ORB1308940-100,BYT-ORB1308940-25,BYT-ORB1308940-5,BYT-ORB1308940-50
Manufacturer:
Biorbyt
Category:
Biochemikalien
Alternative Names:
inhibit, Epigenetic Reader Domain, EpigeneticReaderDomain, Menin-MLL, Menin-MLL interaction, leukemia, Histone Methyltransferase, HistoneMethyltransferase, Inhibitor, differentiation, antiproliferative, Apoptosis, survival, protein-protein, VTP 50469, VTP50469, VTP-50469
Product Description
VTP50469 is a potent, orally bioavailable small molecule that selectively inhibits the Menin-MLL interaction with sub-nanomolar affinity (Ki = 104 pM). It demonstrates robust anti-leukemic efficacy in both cellular assays and in vivo models, making it a valuable chemical probe for researching MLL-rearranged and NPM1-mutant leukemias.
Product Properties
Molecular Weight:
630.82
Purity:
99.55% (May vary between batches)
CAS Number:
[2169916-18-9]
Formula:
C32H47FN6O4S
Target:
Epigenetic Reader Domain,Histone Methyltransferase,Apoptosis
Application Notes
Application Notes:
Solubility: DMSO:125 mg/mL (198.15 mM),10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.34 mM)
