Prion Protein Antibody, IgG2a, Clone: [3F4], Unconjugated, Mouse, Monoclonal
Biozol Catalog Number:
BSS-BSM-70625M
Supplier Catalog Number:
bsm-70625M
Alternative Catalog Number:
BSS-BSM-70625M-100
Manufacturer:
Bioss
Host:
Mouse
Category:
Antikörper
Application:
IHC, WB
Species Reactivity:
Human
Conjugation:
Unconjugated
Alternative Names:
PrP, PrPsc, PrPc
Prion related neurodegenerative diseases, called transmissible spongiform encephalopathies, are observed in many animal species. These diseases involve conversion of normal cellular prion protein (PrPc) into a form that is insoluble and resistant to proteases (PrPSc). The protease resistant form can polymerize into fibrils which accumulate in infected tissues and cause cell death and tissue damage. PrPs have an N-terminal signal sequence and a C-terminal linkage to glycosylphosphatidylinositol anchor. The mature protein is a glycosylated protein that associates with cell membranes. Phosphorylation of PrPC at Ser-43 by Cdk5 promotes proteinase K resistance, prion aggregation, and fibril formation in vitro. In addition, Ser-43 phosphorylation is upregulated in scrapie-infected mouse brain relative to controls. Thus, phosphorylation of Ser-43 may be an important mechanism leading conversion of PrPc to PrPSc and the onset of disease.
