55 kDa leucine rich repeat protein of articular cartilage, MST161, MSTP161, Prelp, PRELP_HUMAN, Prolargin, Prolargin proteoglycan, Proline arginine rich end leucine rich repeat protein, Proline-arginine-rich end leucine-rich repeat protein, Proline/arginine rich end leucine rich repeat protein, SLRR2A.
PRELP (proline/arginine-rich end leucine-rich repeat protein), also known as Prolargin, MST161, SLRR2A or MSTP161, is a 382 amino acid secreted protein that localizes to the extracellular matrix. Belonging to the Class II subfamily of the small leucine-rich proteoglycan (SLRP) family, PRELP contains twelve LRR (leucine-rich) repeats, which are motifs consisting of 20-29 residues that are present in numerous proteins with diverse functions and provide versatile structural framework for the formation of protein-protein interactions. Highly expressed in cartilage, basement membranes and developing bone, PRELP is considered a glycosaminoglycan (GAG)- and collagen-binding anchor protein that associates with the basement membrane heparan sulfate proteoglycan perlecan. PRELP acts as a linker between the extracellular matrix and the cell surface of proteoglycans and may be partially responsible for Hutchinson-Gilford progeria (HGP), an extremely rare genetic disorder that causes premature, rapid aging shortly after birth.
Clonality:
Polyclonal
Concentration:
1ug/ul
Buffer:
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Source:
KLH conjugated synthetic peptide derived from human PRELP
Purity:
Purified by Protein A.
Target:
PRELP
Antibody Type:
Primary Antibody
Application Dilute:
IHC-P(1:200-400), IHC-F(1:100-500)
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