Cyclin C Polyclonal Antibody, PE-Cy7 Conjugated, PE/Cy7, Rabbit
Biozol Catalog Number:
BSS-BS-0282R-PE-CY7
Supplier Catalog Number:
bs-0282R-PE-Cy7
Alternative Catalog Number:
BSS-BS-0282R-PE-CY7-100
Manufacturer:
Bioss
Host:
Rabbit
Category:
Antikörper
Application:
WB
Species Reactivity:
Human
Conjugation:
PE/Cy7
Alternative Names:
CycC, Cyclin-C, SRB11 homolog, hSRB11, CCNC
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
