dishevelled 1 (homologous to Drosophila dsh),dishevelled, dsh homolog 1,dishevelled-1,DRS2,DSH homolog 1,DVL,DVL1L1,DVL1P1,segment polarity protein dishevelled homolog DVL-1.
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
