TANK Antibody
Catalog Number:
ASB-OACA10039
- Images (3)
| Article Name: | TANK Antibody |
| Biozol Catalog Number: | ASB-OACA10039 |
| Supplier Catalog Number: | OACA10039 |
| Alternative Catalog Number: | ASB-OACA10039-100UG,ASB-OACA10039-50UG |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | ELISA, IF, IHC |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human TRAF family member-associated NF-kappa-B activator protein (4-98AA) |
| Conjugation: | Unconjugated |
| Alternative Names: | ITRAF,I-TRAF,TRAF family member-associated NF-kappa-B activator,TRAF2,TRAF-interacting protein. |
| Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. |
| Clonality: | Polyclonal |
| NCBI: | 10010 |
| Purity: | >95% |
| Form: | Liquid |
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Immunofluorescent analysis of HepG2 cells at dilution of 1:100 and Alexa Fluor 488-congu |
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Immunohistochemistry of paraffin-embedded human melanoma cancer at dilution of 1:100 |
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Immunohistochemistry of paraffin-embedded human skin tissue at dilution of 1:100 |
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