Recombinant Human Ubiquitin-like modifier-activating enzyme 6 protein (1-44AA)
Conjugation:
Unconjugated
Alternative Names:
E1-L2,monocyte protein 4,MOP-4,UBA6, ubiquitin-activating enzyme E1,UBE1L2,ubiquitin-activating enzyme 6,ubiquitin-activating enzyme E1-like 2,ubiquitin-activating enzyme E1-like protein 2,ubiquitin-like modifier-activating enzyme 6.
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.
