TGFBR2 Antibody
Catalog Number:
ASB-OACA09848
- Images (3)
| Article Name: | TGFBR2 Antibody |
| Biozol Catalog Number: | ASB-OACA09848 |
| Supplier Catalog Number: | OACA09848 |
| Alternative Catalog Number: | ASB-OACA09848-100UG,ASB-OACA09848-50UG |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | ELISA, IF, IHC |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human TGF-beta receptor type-2 protein (25-159AA) |
| Conjugation: | Unconjugated |
| Alternative Names: | AAT3,FAA3,LDS1B,LDS2,LDS2B,MFS2,RIIC,TAAD2,tbetaR-II,TBR-ii,TBRII,TGF-beta receptor type IIB,TGF-beta receptor type-2,TGF-beta type II receptor,TGFbeta-RII,TGFR-2,transforming growth factor beta receptor II,transforming growth factor beta receptor type IIC,transforming growth factor, beta receptor II (70/80kDa),transforming growth factor, beta receptor II alpha,transforming growth factor, beta receptor II beta,transforming growth factor, beta receptor II delta,transforming growth factor, beta receptor II epsilon,transforming growth factor, beta receptor II gamma,Transforming growth factor-beta receptor type II. |
| Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. |
| Clonality: | Polyclonal |
| NCBI: | 7048 |
| Purity: | >95% |
| Form: | Liquid |
|
|
Immunofluorescent analysis of MCF-7 cells at dilution of 1:100 and Alexa Fluor 488-con |
|
|
Immunohistochemistry of paraffin-embedded human brain tissue at dilution of 1:100 |
|
|
Immunohistochemistry of paraffin-embedded human placental tissue at dilution of 1:100 |
Product Guarantee and Expert Support
