Recombinant Human N-acetyltransferase 8 protein (64-227AA)
Conjugation:
Unconjugated
Alternative Names:
acetyltransferase 2,ATase2,camello-like protein 1,CCNAT,CML1,cysteinyl-conjugate N-acetyltransferase,GLA,Hcml1,kidney- and liver-specific gene product,N-acetyltransferase 8,N-acetyltransferase 8 (camello like),N-acetyltransferase 8 (GCN5-related, putative),probable N-acetyltransferase 8,TSC501,TSC510.
Acetylates the free alpha-amino group of cysteine S-conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).
