Recombinant Human Dual specificity protein phosphatase 26 protein (1-211AA)
Conjugation:
Unconjugated
Alternative Names:
DSP-4,dual specificity phosphatase 26 (putative),dual specificity phosphatase SKRP3,dual specificity protein phosphatase 26,DUSP24,LDP4,LDP-4,low-molecular-mass dual-specificity phosphatase 4,MAP kinase phosphatase 8,mitogen-activated protein kinase phosphatase 8,MKP8,MKP-8,NATA1,NEAP,neuroendocrine-associated phosphatase,Novel amplified gene in thyroid anaplastic cancer,SKRP3.
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).
