RGMA Antibody
Catalog Number:
ASB-OACA05465
- Images (3)
| Article Name: | RGMA Antibody |
| Biozol Catalog Number: | ASB-OACA05465 |
| Supplier Catalog Number: | OACA05465 |
| Alternative Catalog Number: | ASB-OACA05465-100UG,ASB-OACA05465-50UG |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | ELISA, IHC, WB |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Repulsive guidance molecule A protein (153-408AA) |
| Conjugation: | Unconjugated |
| Alternative Names: | repulsive guidance molecule A,repulsive guidance molecule family member a,RGM,RGM domain family member A,RGM domain family, member A. |
| Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. |
| Clonality: | Polyclonal |
| NCBI: | 56963 |
| Purity: | >95% |
| Form: | Liquid |
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Immunohistochemistry of paraffin-embedded human heart tissue at dilution of 1:100 |
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Immunohistochemistry of paraffin-embedded human lung tissue at dilution of 1:100 |
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Western Blot All lanes: GCDH antibody at 12ug/ml Lane 1: Mouse brain tissue |
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