USP30 Antibody
Catalog Number:
ASB-OACA05159
- Images (3)
| Article Name: | USP30 Antibody |
| Biozol Catalog Number: | ASB-OACA05159 |
| Supplier Catalog Number: | OACA05159 |
| Alternative Catalog Number: | ASB-OACA05159-100UG,ASB-OACA05159-50UG |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | ELISA, IHC, WB |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Ubiquitin carboxyl-terminal hydrolase 30 protein (101-400AA) |
| Conjugation: | Unconjugated |
| Alternative Names: | deubiquitinating enzyme 30,ubiquitin carboxyl-terminal hydrolase 30,ubiquitin thioesterase 30,ubiquitin thiolesterase 30,ubiquitin-specific protease 30,ubiquitin-specific-processing protease 30,ub-specific protease 30. |
| Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkins ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves Lys-6- and Lys-11-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at Ser-65 (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). |
| Clonality: | Polyclonal |
| NCBI: | 84749 |
| Form: | Liquid |
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Immunohistochemistry of paraffin-embedded human breast cancer at dilution of 1:100 |
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Immunohistochemistry of paraffin-embedded human colon cancer at dilution of 1:100 |
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Western blot All lanes: USP30 antibody at 7ug/ml+ Mouse lung tissue Goat polycl |
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