Recombinant Human ADP-ribosylation factor-like protein 6-interacting protein 1 protein (93-133AA)
Conjugation:
Unconjugated
Alternative Names:
ADP-ribosylation factor GTPase 6 interacting protein 1,ADP-ribosylation factor-like 6 interacting protein 1,ADP-ribosylation factor-like protein 6-interacting protein 1,aip-1,AIP1,apoptotic regulator in the membrane of the endoplasmic reticulum,ARL-6-interacting protein 1,ARL6IP,ARMER,SPG61.
Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport (By similarity). Plays a role in the formation and stabilization of endoplasmic reticulum tubules (PubMed:24262037). Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself (PubMed:12754298). May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (PubMed:10995579).
