Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish
Immunogen:
The immunogen is a synthetic peptide directed towards the N-terminal region of MOUSE Yod1
Alternative Names:
Hshin7, 6330564D18Rik, 9930028C20Rik
Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. Yod1 may act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCPs axial channel. Yod1 mediates deubiquitination of both Lys-48- and Lys-63-linked polyubiquitin chains. It is able to cleave both polyubiquitin and di-ubiquitin.