HLA-DMB Antibody - N-terminal region
Catalog Number:
ASB-ARP63380_P050
- Images (3)
| Article Name: | HLA-DMB Antibody - N-terminal region |
| Biozol Catalog Number: | ASB-ARP63380_P050 |
| Supplier Catalog Number: | ARP63380_P050 |
| Alternative Catalog Number: | ASB-ARP63380_P050-25UL,ASB-ARP63380_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Human, Rat |
| Alternative Names: | RING7, D6S221E |
| HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. |



