GAPVD1 Antibody - N-terminal region
Catalog Number:
ASB-ARP42451_P050
- Images (3)
| Article Name: | GAPVD1 Antibody - N-terminal region |
| Biozol Catalog Number: | ASB-ARP42451_P050 |
| Supplier Catalog Number: | ARP42451_P050 |
| Alternative Catalog Number: | ASB-ARP42451_P050-25UL,ASB-ARP42451_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human GAPVD1 |
| Alternative Names: | RAP6, GAPEX5, GAPex-5 |
| GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras. |
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Human Brain |
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WB Suggested Anti-GAPVD1 Antibody Titration: 0.25ug/ml Positive Control: HepG2 cell lysate |
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GAPVD1 antibody - N-terminal region (ARP42451_P050) in Human HepG2 using Western Blot |
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