Bovine, Canine, Equine, Guinea pig, Human, Mouse, Porcine, Rat
Immunogen:
The immunogen is a synthetic peptide directed towards the c terminal region of mouse Foxa3
Alternative Names:
Hnf3, Hnf-3, Hnf3g, Tcf3g, Hnf-3g, Tcf-3g
Foxa3 is a transcription factor that is thought to act as a pioneer factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Foxa3 is originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Foxa3 interacts with the cis-acting regulatory regions of these genes.Foxa3 is involved in glucose homeostasis, activates GLUT2 transcription and regulation of neuronal-specific transcription. Foxa3 is also involved in regulation of spermatogenesis, required for the maintenance of the testicular germ cell population and male fertility.